Racial and Ethnic Gap In Rates of Invasive Second Breast Cancer

Women diagnosed with ductal carcinoma in situ (DCIS) before 2000, especially native Hawaiian and Filipino women, have a greater chance of developing invasive second breast cancers (SBC), according to a study published in JAMA Open Network.

“This cohort study including 6221 women found that Native Hawaiian and Filipino women were at significantly higher risk than White women of developing both invasive ipsilateral SBC [iiSBC] and invasive contralateral SBC [icSBC],” wrote the team, led by Dr. Kekoa Taparra, Ph. D. of Stanford Health Care in California.

“This cohort study suggests that Native Hawaiian women, Filipino women, and women who received a diagnosis of DCIS before 2000 have higher odds of developing both iiSBC and icSBC. It also suggests that women younger than 50 years and Japanese women have an increased risk for developing iiSBC. This study highlights racial and ethnic disparities in the risk of developing invasive SBC that were not, to our knowledge, previously appreciated among Native Hawaiian women and subpopulations of Asian American women compared with White women. This finding may help oncologists understand the association of race and ethnicity with the risk of developing invasive SBC in these understudied populations,” concluded the team.


Taparra K, Fukui J, Killeen J, Sumida K, Loo LWM, Hernandez BY. Racial and Ethnic Disparities in Rates of Invasive Second Breast Cancer Among Women With Ductal Carcinoma In Situ in Hawaiʻi. JAMA Netw Open. 2021;4(10):e2128977. doi:10.1001/jamanetworkopen.2021.28977. Published online October 20, 2021, at https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2785310?resultClick=1. Accessed November 1, 2021.

Allegretto, Amerigo. Some minority women more at risk for second breast cancers. AuntMinnie.com October 20, 2021, at https://www.auntminnie.com/index.aspx?sec=sup&sub=wom&pag=dis&ItemID=133814. Accessed November 1, 2021.

Odds for women diagnosed with DCIS before 2000 for developing invasive secondary breast cancers.